Last season’s Supporters’ Shield winners take on the reigning MLS Cup champions in Foxborough.
Of the two, New York City FC are far more well-placed to make the play-offs, although their form is alarming.
On Wednesday, the Boys in Blue were beaten 2-1 at Red Bull Arena by a D.C. United side who are rock bottom of the overall standings.
This means NYCFC have lost back-to-back home matches for just the third time, also doing so as an expansion club in 2015 and last season.
Overall, despite having lost five of their last six, Nick Cushing’s side are fourth in the east.
Baring a miracle, New York City are not going to miss the play-offs, but are set to go into them with no momentum or confidence at all.
New England Revolution meantime are down in ninth, just one point below the all-important dotted line.
The Revs are now winless in four though, following the mid-week home scoreless draw with strugglers Chicago Fire.
Bruce Arena’s side set a new MLS points record in 2021, but need victories if they’re to avoid seeing their season end prematurely on Decision Day.
Who will claim a huge victory in Boston?