These two have only ever met once before, with Portland winning 1-0 at Providence Park in March 2020 in, what was, Nashville's first-ever away match. In Tennessee, the Boys in Gold were unbeaten in 25 matches before seeing that streak end a fortnight ago.
Both teams to score is 3/4.
Nashville to win and both teams to score is 11/4.
Hany Mukhtar is 7/2 to break the deadlock and 21/20 to score anytime.
Can Portland Timbers climb into one of those all-important Western Conference play-off places?
On Wednesday night, a quick-fire brace from Santiago Moreno saw the Timbers beat Houston Dynamo 2-1 at Providence Park.
Having hammered Colorado Rapids 3-0 last weekend, Giovanni Savarese's side have now won back-to-back games for the first time since last year's play-offs.
So, last season's MLS Cup Finalists are up to eighth in the west, hoping to leap above the play-off line with another victory here.
Nashville SC meanwhile are looking to get back on track following recent disappointments.
First, a fortnight ago, the Coyotes' 25-match unbeaten home streak came to an end at the hands of SKC, losing in Tennessee for the first time since November 2020.
Then, on Wednesday night, Gary Smith's side faced Orlando City at Exploria Stadium in the club's first-ever U.S. Open Cup quarter-final.
Hany Mukhtar broke the deadlock in Florida, only for the home side to equalise deep in stoppage time; cue a penalty shootout.
Alex Muyl and Eric Miller were both unsuccessful from 12 yards, meaning it was Orlando who advanced to the semis.
Back in MLS, Nashville remain fifth in the west having won four of their last eight, including demolishing D.C. United last weekend.
But, the home side could well be feeling a hangover following their mid-week cup heartbreak in the Sunshine State.
If that is the case, Portland Timbers are primed to take advantage at Geodis Park.
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