Houston are unbeaten in five meetings with D.C. United, winning two. The Dynamo have won six of their last 12 visits to Washington in all competitions. Both teams have scored in five of their last six encounters.
Both teams to score is 7/10.
Taxiarchis Fountas is 5/1 to break the deadlock and 15/8 to score anytime.
After back-to-back derby defeats, can Houston Dynamo get back on track as they make the long 1,474 mile journey north-east to the capital?
A fortnight ago, despite leading with just three to play, el Naranja somehow contrived to lose 2-1 to historic rivals FC Dallas in Frisco.
Then, last weekend, déjà vu as they welcomed Copa Tejas neighbours Austin FC to PNC Stadium.
Sebastián Ferreira opened the scoring after just five minutes, spotting the keeper off his line so guiding the ball home from 61 yards out.
This is the longest-range goal scored in MLS since Wayne Rooney netted from all of 68 yards for D.C. United against Orlando three years ago.
But, it proved ultimately worthless to Houston who were beaten 2-1, with Austin's winner coming mid-way through the second period.
Before this, Paulo Nagamura's team were unbeaten in five games, but those successive defeats have seen them slip down to seventh in the west.
Meanwhile, D.C. United come into this cross-conference affair rock bottom of the east.
Their poor start saw Hernán Losada sacked as Head Coach on 20 April, with interim manager Chad Ashton then winning his first match at the helm.
A fortnight ago, Taxiarchis Fountas' brace helping D.C. to a 3-2 victory over New England Revolution.
However, the Black-and-Red firmly came crashing back down to earth last weekend, swatted aside 3-0 by Columbus Crew at Lower.com Field.
All in all, this is a very tough game to call, so will either claim three important points at Audi Field?
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