Given that these two teams are, just about, above their respective play-off lines, this is a pivotal fixture in Ohio’s capital.
Hosts Columbus Crew saw their mini-unbeaten streak come to end on Tuesday night, beaten 2-1 by Inter Miami in Fort Lauderdale.
Cucho Hernández on target, his ninth goal in 13th MLS appearances, in a game that concluded almost four and a half hours after it began, due to weather delays.
That is only the Black and Gold’s second defeat since 21 May, although they’ve drawn ten of their last 17 outings.
So, Caleb Porter’s team are only just in the play-off places, with their last three games, against RBNY, Charlotte and Orlando, all very tough.
Over in the Western Conference, every points also counts for Portland Timbers.
Giovanni Savarese’s side have found form at just the right time, winning four in a row, including last weekend’s 1-0 victory over Minnesota United.
Dairon Asprilla’s header proving to be the difference at Providence Park.
So, the Timbers sit sixth in the west, enjoying a five-point buffer over eighth place LA Galaxy, although LA have a game in hand.
This one at Lower.com Field could go either-way.