Columbus won 3-2 when these two last met in October but, before that, Orlando had won five consecutive encounters with the Crew. The Lions have won their last two visits to Ohio's State Capital, despite not winning any of their first four.
Both teams to score is 3/4.
Both teams to score and over 2.5 goals is 6/5.
Columbus Crew to win and over 2.5 goals is 15/8.
Lucas Zelarayán scored and provided two assists in the Crew's last meeting with Orlando. The Armenian international is 9/2 to break the deadlock and 11/8 to score anytime.
Can Orlando City continue their very impressive start to the season?
Last weekend, Ercan Kara header home his first goal for his new club with his side beating ten-man Chicago Fire 1-0 at Exploria Stadium.
This means Óscar Pareja's side have accumulated 11 points from their first seven games of the season, leaving them second in the Eastern Conference.
Since joining Major League Soccer, the Lions highest finish is fourth, but they are looking good to, potentially, break that record this season.
Columbus Crew meanwhile picked up their second MLS Cup in 2020, before adding the Campeones Cup to their cabinet last September.
This season, Caleb Porter's side started by amassing eight points from their first four games, but have since suffered back-to-back defeats.
Last weekend, Eloy Room's calamitous error with less than two minutes on the clock saw the Crew go down 1-0 to Philadelphia Union in Chester.
This has seen the Black and Gold drop down to seventh, looking to avoid a third successive defeat.
Will there be a winner at Lower.com Field?
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