Columbus Crew are unbeaten in four meetings with Nashville, winning two and drawing two. This includes an extra time victory in the 2020 Conference semi-finals, en route to lifting MLS Cup.
Both teams to score is 11/10.
Columbus to win and over 2.5 goals is 13/5.
Lucas Zelarayán is 9/2 to break the deadlock and 7/4 to score anytime.
The team in gold meet the team who's home colours are 'electric gold' in a cross-conference affair in Ohio.
Columbus Crew maintained their unbeaten start to the season a fortnight ago thanks to Darlington Nagbe's 95th minute equaliser against New York Red Bulls.
Caleb Porter though will be wondering how his side didn't win in New Jersey after both Gyasi Zardes and Derrick Etienne Jr. missed open goals in the second half.
Nevertheless, the Crew have eight points to their name, looking to make it three wins out of three at home.
Nashville SC meanwhile have moved over to the Western Conference this season and are beginning the campaign with eight consecutive away games.
Gary Smith's side kicked off with a shock victory over Seattle before a credible draw at Allianz Field with Minnesota United.
Since then though, the long road trips have been less enjoyable, going down 2-0 at FC Dallas and then 2-1 at Real Salt Lake.
In the latter, Dax McCarty was sent off in the 95th minute for stamping on an opponent, making his frustrations known.
Their home opener at Nashville Fairgrounds Stadium against Philadelphia will take place on 1 May, but the Coyotes still have four more away games to negotiate before then.
Will Columbus make home advantage count at Lower.com Field?
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