Charlotte FC have lost all four MLS away matches so far. Colorado are unbeaten this season at Dick's Sporting Goods Park, losing just two of their last 26 matches on home turf.
Over 2.5 goals is 9/10.
Over 2.5 goals and both teams to score is 6/4.
Colorado to win and over 2.5 goals is 6/4.
Andre Shinyashiki is 5/1 to break the deadlock and 13/8 to score anytime.
Can Charlotte FC improve their away form as they make the cross-conference, 1,547 mile journey west to Denver?
The expansion club have impressed so far, beating New England, Cincinnati and Atalanta to date, all at Bank of America Stadium.
Last weekend, Miguel Ángel Ramírez's side faced a Revs rematch but, this time, were narrowly beaten 2-1.
Christian Ortiz's stunning late strike unable to spark a comeback in Foxborough.
This means Queen City have lost all four MLS away matches so far, but did win on the road in the U.S. Open Cup on Wednesday night.
Ortiz and Harrison Afful with the goals as they, just about, overcame USL1 club Greenville Triumph SC 2-1 after extra time in South Carolina.
Now, will CLTFC win on the road in Major League Soccer at the fifth attempt?
Colorado Rapids meanwhile were the best in the west last season, but aren't living up to those lofty expectations in 2022.
Robin Fraser's side come into this one following back-to-back away wins, both 3-1, against FC Dallas and then Minnesota United.
Back in Commerce City, the Rapids are unbeaten this season, beating Atlanta and SKC, but they're still currently tenth in the west.
Will it be an historic occasion for Charlotte at Dick's Sporting Goods Park?
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