The last 11 meetings between these two have produced 38 goals with both teams scoring in six of their last eight encounters. Since winning their first two trips to Chicago in 2015, Orlando are winless in six matches in Illinois.
Both teams to score is 7/10.
Draw and both teams to score is 7/2.
Xherdan Shaqiri is 15/2 to break the deadlock and 12/5 to open his MLS account.
Alexandre Pato is 17/2 to open the scoring and 11/4 to score in consecutive games.
After a solid opening day victory, can Orlando City secure back-to-back wins to start the 2022 season?
A week ago, the Lions beat Club de Foot Montréal 2-0 at Exploria Stadium.
Alexandre Pato opened the scoring with his first-ever MLS goal, following an injury-hit 2021 campaign, before Benji Michel secured the win shortly after.
Óscar Pareja's side finished sixth in the Eastern Conference last season before being eliminated in the first round of the play-offs by Nashville.
But, having lost Nani, Chris Mueller and Daryl Dike in the off-season, they'll need their new-look forward line to hit the ground running.
$9 million signing Facundo Torres made his debut against Montréal and linked-up nicely with a fit and hopefully firing Pato.
Will the Lions now continue their 100% start in this one on the road?
Chicago Fire meanwhile played out a generally uneventful goalless draw with Inter Miami at DRV PNK Stadium in their opener.
Under new manager Ezra Hendrickson, the Fire have massively revamped their squad in the off-season, aiming to improve on last season's 22nd place finish.
Xherdan Shaqiri and Kacper Przybyłko makeup the new-look forward line and both will make their debut in the Windy City in this one.
Roared on by a big crowd at Soldier Field, will Chicago claim three points?
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