These two clubs are currently level on points, which is bad news for both as it means they’re, almost certainly, out of play-off contention.
Last weekend, Charlotte FC beat New York City 1-0 at Bank of America Stadium.
Daniel Ríos was the match-winner, before Christian Fuchs was sent off for a flying elbow.
This means Queen City are just the second expansion club to win home and away against the reigning MLS Cup champions.
Miami Fusion managed this feat over D.C. United in 1998 although, with only 12 clubs in the league back then, they did have six attempts at it.
In the present, Christian Lattanzio’s team have lost seven of their last nine, only beating NYCFC since 9 July.
So, Charlotte are 11th in the east and their play-off push could mathematically end this weekend.
The same can be said of Chicago Fire, although they’re not going down without a fight.
Ezra Hendrickson’s side ended their five-match winless streak last weekend, beating Inter Miami 3-1 in Bridgeview.
18 year old Jhon Durán with a memorable brace, while Xherdan Shaqiri was on target in-between.
However, the Fire could not build on that on Tuesday, beaten 3-2 by in-form CF Montréal, despite a pair of Shaqiri penalties in Quebec.
Chicago have only featured in the post-season once since 2012, and that fact isn’t about to change.
Who will prevail at Soldier Field?