Both teams to score is 3/4.
Cucho Hernandéz is 15/2 to break the deadlock and 5/2 to continue his blistering start to life in black and gold.
Two teams, either side of the Eastern Conference play-off line, meet in a crucial clash at Bank of America Stadium.
Of the two, Columbus Crew are two places and four points better off, largely thanks to their recent impressive form.
Caleb Porter’s men were held to a goalless draw by New England Revolution last weekend, despite dominating at Lower.com Field.
While they’d have been hoping to win that game, this extends the Crew’s unbeaten streak to nine matches, winning four of these.
Will the Black and Gold’s streak continue in North Carolina?
Meantime, Charlotte FC suffered their biggest-ever defeat last weekend, hammered 4-0 by Toronto FC.
Queen City conceded just the four times in the first half at BMO Field with Christian Fuchs then sent off after the break.
So, that’s now back-to-back defeats for Christian Lattanzio’s team, losing 3-2 to Inter Miami, despite leading 3-2 in the Sunshine State.
Back on home turf, the expansion club will fancy their chances of three points.