Recommended bets
Northampton have won four of their last six matches against Colchester, including a 1-0 victory in the reverse fixture in August.
Both teams to score NO is 4/5.
Northampton Town to win and both teams to score NO is 13/8.
Louis Appéré is 5/1 to break the deadlock and 13/8 to score anytime.
Match preview
Will Northampton Town climb into the automatic promotion places?
The Cobblers could only draw 0-0 a Port Vale last weekend but this means they've only lost one of their last seven games, winning four.
As a result, Jon Brady's team sit fourth, just one point behind Exeter City who occupy that final promotion spot.
Colchester United meantime are fighting for their lives at the other end of the table.
The U's held Carlisle United to a 2-2 draw a week ago, leading through Tyreik Wright before conceding late on.
So, under interim manager Wayne Brown, they've only lost one of six games but are just two places and five points above danger.
Will there be a winner at Sixfields Stadium?
Northampton Town team news
Louis Appéré, who joined from Dundee United on Deadline Day, has already scored once for his new club and will continue to lead the line.
Chanka Zimba and Joseph Mills are both likely to miss this one due to injury.
Colchester United team news
The visitors are without goalkeeper Dean Gerken, left-back Ryan Clampin and young midfielder Noah Chilvers due to injury.
Freddie Sears will lead the line, looking to add to his 13 goals this season.
League Two table:
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