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These two have met three times, all since Harrogate were promoted to the EFL in 2020, producing one win a piece and one draw. Back in August, Harrogate enjoyed a 2-0 victory at Brisbane Road.
Both teams to score is 5/6.
Under 2.5 goals is 4/6.
Match preview
After a throughly entertaining, but eventually heartbreaking, outing on Tuesday, can Harrogate Town bounce back?
The Sulphurites led 1-0 and then 3-1 away to Exeter City in midweek but somehow managed to lose 4-3 down at St James' Park.
This means Simon Weaver's side are now winless in three matches, only claiming all three points in two of their last 12 outings.
As a result, Harrogate are down in 15th but still sit a whopping 12 points clear of the relegation places.
Leyton Orient are one place and five points below their hosts.
Kenny Jackett's men are in horrendous form as last Saturday's 2-0 home defeat to Salford City means they haven't won in nine, losing seven of these.
Since their last victory, over Swindon on 7 December, Orient have dropped from seventh, the last play-off place, all the way down to 16th.
Who will claim three important points at Wetherby Road?
Harrogate Town team news
Both centre-forwards Luke Armstrong and Jack Muldoon scored in midweek but Harrogate were still beaten.
Alex Pattison could be another man to watch for Harrogate, after scoring a brace last weekend.
Leyton Orient team news
Striker Frank Nouble has now made 26 appearance for Colchester and now Orient this season without scoring.
Captain Darren Pratley, now 36, is a key figure.
League Two table:
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