Both clubs have play-off aspirations but, right now, both find themselves outside the top six positions.
Portsmouth start the weekend five places and four points above their hosts, currently in seventh.
Danny Cowley’s side have actually drawn their last four league matches, most recently a goalless stalemate with Derby.
In the FA Cup meantime, having dumped out Milton Keynes, Pompey have a glamour trip to Tottenham to look forward to in the new year.
The last time those two met in that competition, Portsmouth won 2-0 after extra time at Wembley to reach the 2010 final.
Here, they’ll be taking on a Wycombe side who, having reached last season’s play-off final, were expecting to make another serious play-off push.
The Chairboys though start the weekend 12th, having won just one of their last five league matches.
Gareth Ainsworth’s team haven’t been in action for 15 days, so should be raring to go at Adams Park.