Bizarrely, the last 19 meetings between these two have produced nine wins apiece and one draw. The Lions won 1-0 at the Ramón Sánchez Pizjuán last season but, before that, had only won two of 26 visits there, dating back to 1993.
Under 2.5 goals is 8/11.
Draw and under 2.5 goals is 3/1.
Lucas Ocampos is 13/2 to break the deadlock and 9/4 to score anytime.
Will Athletic Club sneak into a European place on the final day?
Last weekend, Marcelino's men kept their top seven hopes alive, beating Granada 2-0 at San Mamés.
Álex Berenguer broke the deadlock before Asier Villalibre secured the win.
This means the Lions have won nine times in 2022, only losing five La Liga matches since Christmas Day.
As a result, Athletic kick off eighth, one point below Villarreal who occupy the Europa Conference League play-off round spot.
Given that Athletic Club boast the superior head-to-head, all they need to do is better Villarreal's result to snatch seventh place.
With the Yellow Submarine facing Barcelona away, Marcelino's team will be confident that, if they can win this one, it would be enough.
That won't be an easy task though against a Sevilla side who've secured Champions League qualification.
Los Nervionenses achieved this last Sunday, drawing 1-1 with Atlético Madrid at the Metropolitano, thanks to Youssef En-Nesyri's late equaliser.
Julen Lopetegui's side have now drawn four successive matches and 11 of their last 17 games, winning just four of those.
This has ended Sevilla's hopes of a first title since 1946 and, at one point, their top four spot looked under serious threat.
Here, a draw might be enough for Athletic, so will the Basque giants be back in Europe after this one at Estadio Ramón Sánchez Pizjuán?
Sevilla team news
Anthony Martial isn't going to feature in a Sevilla shirt again with his loan spell having been derailed by injury.
Here Youssef En-Nesyri, who scored just his fifth goal of the season last weekend, could lead the line.
In support, Papu Gómez and Lucas Ocampos started last weekend but Tecatito Corona or Munir El Haddadi could come in.
Centre-back duo Diego Carlos and Jules Koundé are both highly likely to depart following this one.
Athletic Bilbao team news
Iñaki Williams will be looking to add to his eight goals this season, having featured in 230 successive La Liga matches, dating back to April 2016.
Asier Villalibre and Álex Berenguer both scored off the bench against Granada so either or both could come in alongside.
At centre-back, with all options available, Iñigo Martínez and Yeray Álvarez will keep their places, chosen over Dani Vivian and Unai Núñez.
La Liga table:
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