Both of these clubs boast 100% records at the moment, so something will have to give in Seville.
Last weekend, a pair of Borja Iglesias penalties saw Real Betis beat Mallorca 2-1 at Son Moix.
Five days earlier, los Verdiblancos began the campaign by swatted aside Elche 3-0 at home.
After finishing fifth and lifting the Copa del Rey last season, many were tipping Manuel Pellegrini’s team for a strong campaign this time round.
Here, will Béticos begin a campaign with three consecutive wins for the first time since 2011?
Meantime, Osasuna have also played two and won two.
On the opening night of the season, los Rojillos battled to a 2-1 victory over Sevilla before, last Saturday, beating Cádiz 2-0, also at El Sadar.
Chimy Ávila has scored in both matches so far, dispatching a penalty last weekend, with Kike also converted from 12 years against Cádiz.
Bizzrly, Osasuna have been awarded three spot-kicks this season, with three different players scoring them; Aimar Oroz being the other.
More importantly, having finished tenth or 11th since promotion in 2019, Jagoba Arrasate’s team look set to end up even higher this time round.
This one at Estadio Benito Villamarín could go either-way.