Recommended bets
Alavés won 1-0 at Mendizorrotza in September but that was their first victory over Atlético since 2003, which is when they last beat Atleti away.
Atlético Madrid to win and both teams to score NO is 1/1.
Atlético Madrid to win and under 2.5 goals is 2/1.
João Félix has scored five goals in his last seven appearances. He is 5/1 to break the deadlock and 13/8 to score anytime.
Match preview
They're not going to retain their La Liga title but it could still be a big end to the season for Atlético Madrid.
Last time out, los Colchoneros beat city-rivals Rayo Vallecano 1-0 at Campo de Fútbol de Vallecas with Koke getting the only goal just after half time.
This means Atleti have now won five successive league games for the first time since December/January last season.
In this time, Diego Simeone's side have also kept their Champions League dreams alive, knocking out Manchester United with a 1-0 victory at Old Trafford.
They'll return to the city this forthcoming Tuesday to take on Manchester City with the second leg eight days later.
Back in La Liga, Atlético are fourth, four points clear of Real Betis, aiming to ensure they're back in the Champions League next season too.
Deportivo Alavés meanwhile look like returning to the Segunda División for the first time since 2015/16 given their current predicament.
A fortnight ago, they were 2-1 up at home to Granada, Gonzalo Escalante and Manu Vallejo scoring, so were in pole position for a vital victory.
However, their relegation rivals scored in the 77th and 87th minutes to leave Vitoria-Gasteiz with a huge three points.
This defeat means José Luis Mendilibar's side are now winless in five and remain 19th, but are now five points from safety.
Alavés still have to play Mallorca and Cádiz, the two teams directly above them, but need points now to make those games meaningful.
Will Atleti be far too strong at the Wanda Metropolitano?
Atlético Madrid team news
Diego Simeone brings his side north depleted for a variety of reasons.
Ángel Correa's late red card against Rayo means he is suspended, while Daniel Wass, Šime Vrsaljko, Thomas Lemar and Matheus Cunha are injured.
Héctor Herrera sat out Mexico's win over El Salvador on Wednesday suspended, having played the first two games of the window, so should be fresh to start.
Yannick Carrasco will serve the third and final match of his UEFA suspension during Tuesday's trip to Manchester so, if fit, will surely start this one.
Luis Suárez has only started one of Atleti's last eight but after scoring against Chile on Tuesday, could come get the nod here.
Deportivo Alavés team news
The most surprising aspect of Alavés' 3-2 defeat to Granada was the fact neither goal was scored by Joselu as he's netted 52% of their La Liga goals this season.
José Luis Mendilibar took off their talisman at 2-1 up, but he then wasn't on when Alavés needed a goal later on; surely this mistake won't be made again.
Their joint-second top-scorer Víctor Laguardia, who's bagged two, will continue to captain the side from centre-back.
La Liga table:
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