River Plate were 1-0 down from the first leg, but produced an epic second leg display in Brazil to oust Cruzeiro from the Copa Libertadores.
Carlos Sanchez drilled home the opener for River Plate on 20 minutes.
On the stroke of half-time Jonathan Maidana headed home for River Plate from a corner for 2-0.
And, the River Plate victory was completed on 52 minutes through a seriously classy goal from Teofilo Gutierrez.
River Plate are now in the semi-finals of the Copa Libertadores.