Lanus 0 – Universitario Peru 0 (Copa Libertadores, April 15, 2010) Universitario finished second in Group Four and Lanus third. The match was marred by fighting between opposition players at the final whistle which meant riot police had to be called in.
Blooming 1 – Libertad 2 (Copa Libertadores, April 15, 2010) Libertad progressed to the next round after coming from behind after Julio Hurtado had given Blooming the lead. Adelberto Roman and Rodolfo Gamarra scored for the Paraguayans.
Colo Colo 1 – Cruzeiro 1 (Copa Libertadores, April 15, 2010) Cruzeiro qualified for the last 16 as one of the best placed runners-up. Thiago got the opener for Cruzeiro, Rodrigo Millar equalised.
Velez Sarsfield 4 – Deportivo Italia 0 (Copa Libertadores, April 15, 2010) Victor Zapata, Lopez (2) and Emiliano Papa were on the scoresheet for the home side.
Palmeiras 1 – Atletico PR (Copa do Brazil, April 15, 2010) Robert fired home the only goal of the game in the 14th minute.