For the second successive friendly, Lionel Messi did not come off the bench, due to a foot injury.
And, for the second time this week, Argentina scored two goals to win an international friendly.
On Saturday, Argentina defeated El Salvador, on Tuesday the World Cup finalists saw off Ecuador.
Sergio Aguero grabbed the Argentina opener on 8 minutes. Miller Bolanos equalised for Ecuador on 24.
Javier Pastore won the game for Argentina with a volley just before the hour mark.