It’s the first O Clássico of the season as Portugal’s top two go head-to-head.
Between them, these two have won 19 of the last 20 Portuguese league titles, with this trend looking set to continue.
Benfica kick off three points clear at the top, having enjoyed a remarkable start to the campaign.
Roger Schmidt’s team have won eight of nine league games, the only exception a goalless draw against Vitória de Guimarães.
Meanwhile, in the Champions League, the Eagles have come through two rounds of qualifying, beaten Juventus in Turin and held Paris-Saint Germain to two draws.
Despite all of that, last weekend, Benfica needed a penalty shootout to see off fourth-tier Caldas in the Taça de Portugal.
Porto meanwhile, having demolished Anadia 6-0 last Sunday, will be confident of ending Benfica’s unbeaten start to the campaign.
Sérgio Conceição’s side lost to Rio Ave back in August, which is why they kick off three points adrift of Benfica.
In the Champions League this month, the Dragões have beaten Bayer Leverkusen both home and away, thereby moving up to second in Group B.
At home, Porto have lost just one of their last 47 league matches, with Benfica only beaten them on their own turf twice in 11 years.
So, will a raucous Estádio do Dragão roar their team onto victory?