Wolves have won five of their last seven meetings with West Ham, despite only winning seven of their previous 27 encounters. West Ham are looking for successive home victories over Wolves for the first time in 18 years.
Under 2.5 goals is 8/13.
Draw and under 2.5 goals is 11/4.
After disappointment on Thursday night, can Wolverhampton Wanderers give their European aspirations a serious boost?
In midweek, Wolves travelled to face Arsenal in North London, knowing a victory would see them leapfrog the Gunners in the table.
It was all going to plan for the visitors when Hwang Hee-chan pounced on some calamitous defending and calmly slotting home just ten minutes in.
At this point, Wolves fans had every reason to be confident given that they were unbeaten in 45 league games when scoring first, winning 39.
Arsenal took until the 83rd minute to equaliser before, in the fifth minute of added on time, a shot deflected into his own net off José Sá's gloves.
2-1; bedlam at the Emirates, while Wolves left dejected.
Just 64 hours later, they have the chance to put that right just 4.8 miles across London.
Bruno Lage's side shouldn't be to disheartened as that's only their fifth defeat in 20 outings, dating all the way back to mid-September.
In the table, the Wanderers are seventh which could be enough to see them return to Europe.
Just one place and two points above are West Ham United who've been enjoying their most fruitful continental adventure since 1980/81 this season.
On Friday morning, the draw was conducted and the Hammers found out that they'll play record-winners Sevilla in the Europa League round of 16.
That's obviously a huge tie to look forward to but, before the first leg in Spain on 10 March, it's all about ensuring they're back in Europe next season.
Last time out, David Moyes' men could only draw 1-1 with relegation threatened Newcastle, despite taking the lead through Craig Dawson.
This means the Irons have only won one of their last five, slipping from fourth to sixth in this time-frame.
Who will win a crucial clash at the London Stadium?
West Ham United team news
Having not played for eight days, there's little reason for David Moyes to make too many changes, if any.
Vladimír Coufal is currently out and, at right-back, Ben Johnson could come in for Ryan Fredericks as the deputy.
Further forward, Saïd Benrahma will start as the number ten, flanked by Pablo Fornals and Jarrod Bowen, with Manuel Lanzini a doubt.
Michail Antonio will lead the line, looking for his first goal since New Years' Day.
However, his record against Wolves is poor, failing to score against them in ten appearances, the most games he's played against an opponent without netting.
Wolverhampton Wanderers team news
Given the tight turnaround, Bruno Lage might make changes.
Although, the majority of his XI never changes, most notably the back three of Max Kilman, Conor Coady and Romain Saïss.
Interestingly, Lage switched from a 3-5-2 to a 3-4-3 against Arsenal but, if he wants more stability, Leander Dendoncker could return.
Jonny came off the bench on Thursday, which is notable because it's the Spaniard's first appearance since 15 April due to a knee injury.
In attack, Hee-chan Hwang's opener at Arsenal was his first goal since 23 October, missing four games with a hamstring injury in between.
The Korea Republic international could keep his place, alongside Daniel Podence, in support of Raúl Jiménez.
The Mexican has scored four Premier League goals against West Ham, only netting more often against Everton and Southampton.
Pedro Neto will be looking for more minutes after recent cameo roles as he returns from a long-term knee problem of his own.
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