For the first time since 5 December 2018, Southampton go into a game without Ralph Hasenhüttl at the helm.
Sunday’s 4-1 drubbing at the hands of Newcastle proved to be the Austrian’s 173rd and final game in charge.
The Saints have amassed just five points from their last nine Premier League outings, thereby slipping into the relegation zone.
Here, interim boss Rubén Sellés will hope to guide Southampton through to the round four.
In the previous round, Ché Adams bagged a brace, Dom Ballard also scored, as the Saints swatted aside Cambridge United.
Will this clash prove to be quite as comfortable?
Sheffield Wednesday meanwhile won this competition in 1991, losing in the 1993 final, but are currently enduring a second successive season in the third-tier.
So far, the Owls have won two home ties, seeing off Sunderland and Rochdale, to set up this glamour trip to a Premier League outfit.
Under Darren Moore, Wednesday sit third in League One, and saw off Morecambe in the FA Cup on Friday night.
So, this won’t be an easy tie for Southampton, but will they have simply too much quality at St Mary’s?
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