Despite the fact this is Nashville's third season, this'll be a first ever meeting of these two clubs. Seattle Sounders have only lost seven of their last 61 home games in all competitions.
Seattle Sounders to win is 1/1.
Seattle Sounders to win and both teams to score NO is 9/4.
Raúl Ruidíaz has scored 61 goals in 97 appearance since arriving in MLS. The Peruvian is 15/4 to open the scoring and 5/4 to net anytime.
Will 2022 result in yet more silverware for Seattle Sounders?
Since Brian Schmetzer took over in 2016, Seattle have appeared in four of six MLS Cups, winning the trophy in 2016 and 2019 while losing in 2017 and 2020.
Last season, they reached a first continental final, beating Tigres UANL and then Santos Laguna in the Leagues Cup.
However, they could not become the first MLS side to win that trophy, going down 3-2 to Club León at Allegiant Stadium.
Domestically, despite finishing third in the overall standings, Seattle then made no progress in the play-offs.
Real Salt Lake mustered a grand total of zero shots in 120 minutes but forced a penalty shootout, in which Seattle crashed out in the first round.
Given those two disappointments, the Rave Green are doubly determined to win a trophy in 2022.
Schmetzer's side have already been in action this year, facing F.C. Motagua in the CONCACAF Champions League.
Despite a goalless draw in Honduras, the Sounders cruised to a 5-0 victory in Thursday night's second leg to reach the quarter-finals.
Nicolás Lodeiro, Cristian Roldan, Jordan Morris, Kelyn Rowe and Léo Chú all on target; they'll face Club León in the last eight next month.
Will Seattle now start the MLS season with a Sunday night win?
As for Nashville SC, this is now their third campaign in the league and, in each of the first two, they've managed to make the play-offs.
Last year, Gary Smith's side came third in the Eastern Conference, beating Orlando City in the play-offs before bowing out to Philadelphia on penalties.
Nevertheless, the side from Music City, led by talisman Hany Mukhtar, will be confident of keeping up their 100% play-off record.
Having said that, Seattle are big favourites to win this one at Lumen Field.
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