Inter Milan looked far from their best en route to an opening day win at Lecce, sparking concern ahead of what is expected to prove a highly competitive battle for supremacy in the Italian top-flight.
Spezia, as a result, could well fancy their chances of causing what would be a major upset in Lombardy.
You can bet on the Liguria-based minnows emerging triumphant at the San Siro on Saturday evening at odds of 14/1 with 888Sport.
Fancy a straightforward Inter victory, on the other hand? Then look for Lautaro Martinez to open the scoring this weekend.
The Argentine bagged an assist against Lecce last time out, and, fresh off a 21-goal league haul last time out, will no doubt be confident
Bet on Martinez finding the net against Spezia at any time at odds of 6/1, with Bet365 .
Both Inter and Spezia enjoyed a winning start to the new Serie A campaign last weekend, and will be hopeful of making it six points from six when they go head-to-head on Saturday afternoon at the San Siro.
It is Simone Inzaghi’s hosts who are the overwhelming favourites here, despite having only gotten their efforts to reclaim the Scudetto crown off to a less than convincing start courtesy of a last-gasp Denzel Dumfries winner at newly-promoted Lecce.
The Nerazzurri are again expected to make use of the talents of dynamic duo Lautaro Martinez and the returning Romelu Lukaku from the off, pushing Edin Dzeko to the bench once more.
When it comes to injuries, Inzaghi is set to be without all of Henrikh Mkhitaryan, Danilo D’Ambrosio, and Dalbert on Saturday.
Spezia, meanwhile, too emerged on the right side of the result in what marked their 2nd outing of the season last weekend. Fresh off a 5-1 Coppa Italia drubbing of Como, Luca Gotti’s men put Empoli to the sword by a goal to nil.
They will be forced to make do without Janis Antiste, Kelvin Amian, and Salva Ferrer, but summer arrival Mattia Caldara should again slot in at the back, with fellow signings Albin Ekdal and Daniel Maldini also pushing for respective starting berths.