Both teams are World Cup bound, so who will win this friendly at Baniyas Stadium?
Ghana booked their ticket to Qatar back in March, defeating Nigeria on away goals in the African play-offs.
So, the Black Stars will compete at their fourth World Cup, all since 2006, facing Portugal, Uruguay and Korea Republic.
This is an extremely challenging group, with most expecting Otto Addo’s team to go home without a point to their name,
The same cannot be said of Switzerland, who’ve reached the round of 16 at three of the last four editions, but last went further in 1954.
Murat Yakın’s team were unbeaten in qualification, pipping Italy to first place in Group C.
They begin their World Cup campaign against Cameroon on Thursday, before taking on Brazil and Serbia; the latter could be crucial.
Before all of that, will there be a winner in Abu Dhabi?