West Ham to win and both teams to score (3/1 with Bet365)
West Ham will be looking to produce another massive win against Lyon have stunned Sevilla in the last round.
The Hammers have been in excellent form at the London Stadium this season winning five of their last six there.
Meanwhile, Lyon are having an underwhelming season, currently down in 9th in Ligue 1.
Jarrod Bowen to score first (6/1 with 888Bet)
Bowen has been on fire for West Ham this season.
He marked his return from injury with a goal against Everton on the weekend.
The winger now has 13 goals to his name this term.
Match preview: West Ham United vs Olympique Lyon
West Ham produced a historic win in the Round of 16 as they knocked out Sevilla.
The Hammers managed to eliminate the record holders of the competition by edging the tie 2-1.
Following a 2-1 defeat in Spain, David Moyes' side turned the tie on its head by winning 2-0 at the London Stadium.
The east London club now take on Lyon and the winners of this tie will face either Eintracht Frankfurt or Barcelona in the semis.
Olympique Lyon down in 9th in Ligue 1
Lyon have struggled in Ligue 1 this season as they sit in 9th place.
Over recent weeks, they have dropped points against Reims, Lille and Rennes.
They did however win on the weekend securing a 3-2 win over Angers.
In the Europa League, Lyon knocked out Porto in the Round of 16 as they won 2-1 on aggregate.
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