First leg score: Gent 0-2 Omonia
Having secured a shock victory in Belgium last Thursday, Omonia are in the catbird seat in this tie.
Charalambos Charalambous and Brandon Barker were the scorers at Ghelamco Arena as the Cypriot side left 2-0 winners.
Back in Nicosia, will they complete the job?
In May, Omonia won the Cypriot Cup for the first time in a decade, beating Ethnikos Achna on penalties.
This was just as well because Neil Lennon’s team finished seventh, thereby sneaking into UEFA competition.
So, Omonia will feature in a group stage for a third season in succession, after the Europa League in 2020 and Europa Conference League last season.
Similarly, Gent finished fifth in the Jupiler Pro League last season, but entered in this round after beating Anderlecht in the Belgian Cup Final, also winning on penalties following a goalless draw.
The Buffalos have featured in six UEFA group stages since their first in 2010, but look set for a second successive season in the Europa Conference League.