West Ham have been superb in Europe this season.
The Hammers stunned Sevilla in the last round.
Meanwhile, Lyon are having a tough season and are currently 10th in Ligue 1.
Bowen has 14 goals in total for the Hammers this season.
He scored in the first-leg to give West Ham the lead.
The forward has been their main man this season and he is playing full of confidence.
Match preview: Olympique Lyon vs West Ham United
Lyon are having a thoroughly underwhelming domestic campaign.
They are 10th in Ligue 1 and look set to miss out on European qualification.
Peter Bosz's side have won just twice in their last 7 league matches.
In the Europa League, they earned a 1-1 draw in east London last week.
Tanguy Ndombele pulled back an equaliser for them after they fell 1-0 down.
West Ham United lose at Brentford
West Ham showed signs of fatigue on the weekend as they were well beaten by Brentford.
The Bees won 2-0 in west London as the Hammers lost for the third time in their last five.
They are now 6th in the Premier League and looking to secure a European spot.
David Moyes' side also travel to France with the tie finely poised at 1-1.
The east Londoners took the lead through Bowen before Lyon squared the game up.
Cresswell's first-half red card certainly didn't help their cause.
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