Porto take a slender lead to Rome on Thursday but will fancy their chances of getting the job done.
Sérgio Conceição's side won the first leg 2-1 and another closely contested affair is expected at the Stadio Olimpico.
The Portuguese champions have been impressive in Europe this season, getting results at both the San Siro and away at Ateltico.
The Spaniard is set to keep his place in the line up following his strong showing in the first leg.
Martinez netted a brace at the Estádio do Dragão and he will be full of confidence.
Match preview: Lazio vs FC Porto
Lazio have work to do in the return leg to overturn the 2-1 deficit which they face.
Porto produced a strong performance at the Estádio do Dragão to take the lead in the tie.
A brace from Toni Martínez proved to be the difference between the two sides.
Meanwhile, Mattia Zaccagni found the back of the net for Lazio.
Both teams are enjoying strong domestic campaigns, with Poroto leading the Liga NOS and Lazio 6th in Serie A and four points off the top four.
Lazio Rome team news
Mattia Zaccagni, who scored in the first leg, is suspended after being shown a third yellow in Porto.
Pedro has suffered an ankle injury and will miss the clash.
He joins Francesco Acerbi and Manuel Lazzari on the sidelines.
FC Porto team news
Porto will be missing Wendell on Thursday who remains suspended.
However, Augustin Marchesin is still banned having been sent off against Atletico Madrid.
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