Atalanta produced an impressive display in the first-leg to win 3-2.
Gian Piero Gasperini's side will now be looking to get the job done in Germany.
They will look to frustrate Bayer Leverkusen and a low scoring contest is likely.
Muriel proved to be the match-winner in the first-leg.
The striker netted a brace in Atalanta's 3-2 win in Bergamo.
Match preview: Bayer Leverkusen vs Atalanta
Bayer Leverkusen are having a tricky patch having lost three of their last five in all competitions.
Leverkusen were beaten 1-0 by FC Köln and lost further ground on Borussia Dortmund.
Gerardo Seoane's team are still 3rd but the race for Champions League qualification is really starting to heat up.
The German club suffered a 3-2 defeat in Bergamo vs Atalanta last week and have plenty of work to do in the second-leg.
Atalanta drop points Genoa
Atalanta dropped more points against Genoa on the weekend.
Following their defeat against Roma, their push for Europe was dealt another blow as they were held to a 1-1 draw with 19th place Genoa.
The Bergamo remained 6th in Serie A but are just a point off the Europa League spot.
They now travel to Germany looking to defend their 3-2 lead in the tie.
- 101 Great Goals may earn commission from links on this page. Our content is always original. Note that all of our reviewers are compensated for contributing content to 101 Great Goals. Learn more.