Who will break new ground by reaching the last eight of a UEFA competition?
Gent had to work hard to get this far, requiring a penalty shootout to overcome Qarabağ last month.
Both legs were won 1-0 by the hosts, with Gent then scoring five out of five in the shootout, meaning Davy Roef’s solitary save was enough.
This is de Buffalo’s first knockout phase victory since overcoming Tottenham in 2017, their run that season, confusingly enough, ended by Genk.
To date, Gent’s only quarter-final appearance on the continent came in the UEFA Cup 31 years ago, ousted by eventual winners Ajax.
Despite being fifth in the Jupiler Pro League, Hein Vanhaezebrouck’s team will fancy their chances of victory in this tie.
İstanbul Başakşehir re-enter the Europa Conference League here having topped their group in the autumn, ending up above Fiorentina on head-to-head goal difference.
The Grey Owls made their group phase debut just five seasons ago, but did reach the Europa League round of 16 in 2020, before defeat at the hands of København.
Domestically, Emre Belözoğlu’s team are fifth in the Süper Lig, following Friday night’s 1-0 defeat at Alanyaspor.
So, Gent will certainly be seeking to establish a first leg advantage at Ghelamco Arena.
Gent team news
Defender Bruno Godeau as well as strikers Tarik Tissoudali and Darko Lemajić are all currently injured.
20 year old Gift Orban, who arrived from Stabæk in January, was the only scorer in Sunday’s win over Anderlecht, so will continue to partner Hugo Cuypers in attack.
Cuypers has 19 goals to his name this season, three of which have come in this competition.
İstanbul Başakşehir team news
Don’t expect Mesut Özil to feature in this fixture; he’s made just seven appearances this season due to injury.
Former Manchester United wonder-kid Adnan Januzaj is likely to be on the bench, with Deniz Türüc and Serdar Gürler getting the nod out-wide.
Stefano Okaka, one of Watford, has scored six goals this season, five of which have come in the Europa Conference League.