West Ham have been flawless in the Europa Conference League so are looking to extend that 100% record here.
Including the qualification victory over Viborg, the Hammers have won four out of four in this competition, scoring three goals each time.
In the group, they came from behind to defeat FCSB 3-1 at home before, a week later, seeing off Silkeborg in Denmark.
Manuel Lanzini, Gianluca Scamacca and Craig Dawson on target in that 3-2 success.
West Ham United reached the semi-finals of last season’s Europa League, so are hoping to go even better in a lower-tier competition.
Here, they’ll face a rematch of the 1976 Cup Winners’ Cup Final, a game Anderlecht won 4-2, claiming the first of their five major European honours.
These days, the Purple and Whites are back in a UEFA group stage after a four-year exile, but do currently sit second.
First, Fábio Silva’s late penalty downed Silkeborg in Brussels, before Felice Mazzù’s team battled to a goalless draw at Arena Națională in Bucharest.
Domestically, Anderlecht are down in tenth place, following Sunday’s 1-0 home defeat to Charleroi.
In fairness, West Ham aren’t exactly flying high in the Premier League, sat 15th, despite Saturday’s 2-0 victory over Wolves.
Nevertheless, the Irons should be too strong at Lotto Park.