Coventry will be hoping to return to winning ways when they host the team at the bottom of the division.
Mark Robins' side have been in good goal scoring form this season, averaging 1.3 goals per game.
Meanwhile, Barnsley have struggled to keep goals out, they have conceded on average 1.5 goals per game.
Gyökeres has netted 11 times in the league for Coventry this season.
The striker is currently filling in for the unavailable Matt Godden.
On Saturday, he is once again expected to lead the line for Coventry.
Match preview: Coventry City vs Barnsley
Coventry slipped to a 2-0 defeat to Cardiff during midweek.
The defeat against a struggling Cardiff side leaves them 12th in the league.
Although, they are six points off the playoffs and a good run of form could see them climb back into contention.
The form of Mark Robins' side has been all over the place recently, with two wins and two defeats coming in their last five.
Barnsley secure first win in 13
Barnsley secured their first win in 13 matches as they stunned QPR.
The victory was just their third of the season.
Poya Asbaghi's side produced a huge 1-0 win over the R's with Domingos Quina scoring the only goal.
The Tykes remain bottom of the table but are now six points away from safety and with a game in hand.
Coventry City team news
Coventry will remain without their top scorer Matt Godden.
The striker has had an appendix operation and will the next few weeks.
Godden has ten league goals this season.
Barnsley team news
Aaron Leya Iseka and Liam Kitching are set for a long spell on the sidelines.
Meanwhile, Poya Asbaghi is expected to name an unchanged lineup following his side's shock win over QPR.
- 101 Great Goals may earn commission from links on this page. Our content is always original. Note that all of our reviewers are compensated for contributing content to 101 Great Goals. Learn more.