Bayern have won 20 of 30 matches against Spanish clubs in Munich. However, they've only won three of their last 13 UEFA ties when losing the first leg. Unai Emery has won 21 of his last 23 two-legged European ties as a manager, both defeats coming in charge of PSG. Villarreal have won 15 of 16 ties when winning the first leg at home.
Bayern Munich to win and over 3.5 goals is 13/10.
Bayern Munich to win and both teams to score is 6/4.
Robert Lewandowski has scored 40 goals in his last 33 Champions League appearances. He is 15/8 to break the deadlock, 4/11 to score anytime and 9/2 to niet a third European hat-trick of the season.
After the first leg in Spain, it's Villarreal who boast the lead, but it is only a slender one.
Six nights ago, the Yellow Submarine took a surprise eighth minute lead when Dani Parejo's shot what diverted in by Arnaut Danjuma.
The home side then thought they'd doubled the lead when Francis Coquelin's cross floated into the far corner, but it was disallowed for an offside in the build-up.
Bayern pushed for an equaliser but, in truth, Villarreal came closest to the night's second goal.
Gerard Moreno almost lobbed Manuel Neuer from the halfway line, before Alfonso Pedraza was played in but sliced his effort wide.
So, 1-0 it finished at Estadio de la Cerámica with Unai Emery's side now looking to turn a first leg advantage into a spot in the semi-finals.
El Submarino Amarillo are reigning Europa League winners, but this is their first appearance at this stage of the Champions League for 13 years.
To get here, Villarreal caused a big shock in the round of 16, ousting Juventus thanks to a famous, thumping 3-0 victory in Turin.
Now, the side down in seventh in La Liga are looking to beat another of Europe's established heavyweights.
As for Bayern Munich, that was their first away defeat in the Champions League since 2017, ending their record-breaking run of 22 matches.
However, in the last round, they only draw 1-1 in their first leg in Austria before demolishing RB Salzburg 7-1 back in Bavaria.
This means Julian Nagelsmann's side have scored 30 goals in this competitions so far, winning all six group matches in the Autumn.
Bayern are six-times champions of Europe and, given that they're nine points clear at the top of the Bundesliga, this is their main focus again.
Will the German giants prove unbeatable at Allianz Arena again?
Bayern Munich team news
Julian Nagelsmann loves deploying outlandish, attacking formations and, given his side are a goal down, another could be on show here.
However, they'll be without starting defender Niklas Süle as well as midfielder Corentin Tolisso and Eric Maxim Choupo-Moting.
Thankfully, Alphonso Davies is back, making his first appearance since December in the first leg, and he'll start at left-back.
Lucas Hernández missed the weekend win over Augsburg, but should be fit for this one, joining Davies, Dayot Upamecano and Benjamin Pavard at the back.
In midfield, Leon Goretzka is fit again and that's a huge boost.
Thomas Müller, Serge Gnabry and Leroy Sané could continue as the attacking trio, chosen over Kingsley Coman and Jamal Musiala.
Robert Lewandowski will lead the line, looking to add to his 85 Champions League goals, including two hat-tricks this season.
Villarreal team news
First leg scorer Arnaut Danjuma remains Villarreal's danger man having scored 14 times this season, including six in the Champions League.
Unai Emery heavily rotated his XI for Saturday's draw with Athletic Club but all the key players will return for this one.
They include: Danjuma, Gerard Moreno, Giovani Lo Celso, Francis Coquelin, Dani Parejo, Étienne Capoue, Raúl Albiol and Gerónimo Rulli.
Pervis Estupiñán will continue to deputise at left-back with Alberto Moreno currently out injured.