All eyes will be on Old Trafford and how long it takes Louis van Gaal to establish himself at Manchester United this season.
Guardian pundit Iain Macintosh goes through many of the permutations, making it clear just how much change there has been at Manchester United in recent times.
Besides van Gaal, there is the small matter of Luke Shaw and Ander Herrera, the latter of whom will be fascinating as the first central midfielder brought in by Manchester United for some time.
And, of course, the change to 3-52 – which suits Wayne Rooney and Robin van Persie, but not necessarily a defence that looks a little short on numbers.
Will the David Moyes season be a mere blip for Manchester United or are fans of the Red Devils set for more pain?