With both teams poised on 19 points, Toulouse travel to Lyon and only find themselves behind Les Gones on goal difference in the league table.
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Lyon were on the receiving end of a 4-0 away defeat to league leaders PSG and will look to bounce back in front of their home fans at the Stade de Gerland.
Whereas Toulouse thrashed minnows FC Sochaux-Montbeliard 5-1 last week including a hat trick for Wissam ben Yedder.
It is not yet clear if Lyon striker Bafetimbi Gomis will play after missing the PSG match due to injury.
Gomis is also subject to transfer rumours linking him with a move to the Premier League in January with both West Ham United and Newcastle United declaring their interest.
Both coaches will look to leapfrog the other team and try to build some distance before the winter break starts at the end of the month.
The match kicks off on Thursday December 5, 2013 at 8pm UK time.