Liverpool have never faced Manchester United in European competition before, which will likely come as a surprise, but this is set to change dramatically with two massive Europa League games in a week.
Arguably, the Europa League has never seen as big a tie as Liverpool v Manchester United, quite possibly the biggest game in England.
Certainly, when it comes to English league titles won, Liverpool and Manchester United are way out in front. The pair also have a fair few European trophies between them as well.
Both Liverpool and Manchester United need progression from this tie as winning the Europa League still looks like their best way of securing a spot in the Champions League next season.
In terms of recent results, Louis van Gaal has a great record against Liverpool as Manchester United manager, having won all four games he has coached in this fixture at Anfield and Old Trafford.
But, Jurgen Klopp is beginning to make his mark at Anfield and Liverpool are becoming kings of the comeback so a two-legged tie could be tough for United, who hold somewhat of an advantage with the second leg at home.
Liverpool will be buoyed by their past two results, since losing to Manchester City in the Capital One Cup final on penalties.
Jurgen Klopp’s side crushed Manchester City 3-0 in the Premier League and then produced a fine late comeback with 10 men to win at Crystal Palace on Sunday.
James Milner, who was sent off at Selhurst Park, is available for the games against Manchester United but is a late fitness scare due to illness and Christian Benteke could well be pushing for a place in the starting line-up having won the match almost single handedly at Palace.
Jesse Lingard is suspended for this match but Juan Mata is available for United despite his Premier League red card at West Brom.
LVG will likely trust in the pace provided by the youthful front pairing of Anthony Martial and Marcus Rashford.
Adnan Januzaj and Timothy Fosu-Mensah are ineligible for the Europa League but Antonio Valencia is expected to be on the bench.
Liverpool predicted starting XI: Simon Mignolet, Nathaniel Clyne, Mamdou Sakho, Dejan Lovren, Alberto Moreno, Emre Can, Jordan Henderson, Adam Lallana, Roberto Firmino, Phillipe Coutinho & Daniel Sturridge.
Manchester United predicted starting XI: David De Gea, Matteo Darmian, Chris Smalling, Daley Blind, Marcos Rojo, Michael Carrick, Ander Herrera, Morgan Schneiderlin, Juan Mata, Marcus Rashford & Anthony Martial.
101 Great Goals Liverpool v Manchester United prediction: 1-1