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Recommended bets
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Match preview
In recent seasons, this fixture has gone along-way to deciding the destination of the Premier League title, with no one else claiming the crown since 2017.
Right now though, these two are 13 points apart and, by kick off, Liverpool could find themselves as low as 16th in the table.
Last weekend, the Redsβ put in one of the better performances of the season but still lost, beaten 3-2 by Arsenal.
Darwin NΓΊΓ±ez and Roberto Firmino both bagged equaliser in North London, but a late penalty saw the league-leaders to victory.
This means JΓΌrgen Kloppβs team have won just two league matches this season, the clubβs fewest after eight games for a decade.
In contrast, Manchester City are still unbeaten, winning seven of nine outings, scoring 33 times already.
But, having drawn at both St Jamesβ Park and Villa Park, Pep Guardiolaβs team are still on point off the pace.
In the Champions League meanwhile, both can, almost, start planning for the knockout stages.
The Citizens have qualified, following Tuesdayβs goalless draw with KΓΈbenhavn; MaαΈ₯rez missed a penalty and Sergio GΓ³mez was sent off at Parken.
Liverpool meantime rediscovered their mojo on Wednesday, coming from a goal down to demolish Rangers 7-1 at Ibrox.
Mo Salah bagged the fastest hat-trick Champions League history, timed at six minutes and two seconds.
They need just a point from their final two games to get through.
Will this huge game be exactly what Liverpool need to reinvigorate their season, or will Manchester City be simply too strong at Anfield?
Liverpool team news
Defenders JoΓ«l Matip and Trent Alexander-Arnold went off injured at Arsenal last weekend, and both are out of this one too.
Andy Robertson came on for 22 minutes at Ibrox, so could start for the first time since 7 September.
Thisβll be Virgil van Dijkβs 70th Premier League appearance for Liverpool at Anfield and, amazingly, heβs still never lost one; will this be the day?
Thiago will return in midfield, probably alongside both Fabinho and Jordan Henderson.
Mo Salahβs hat-trick off the bench at Ibrox will surely earn him start here, alongside Darwin NΓΊΓ±ez and Roberto Firmino, both of whom scored at Arsenal and then against Rangers.
Luis DΓaz has been ruled out until after the World Cup.
Manchester City team news
Pep Guardiola meanwhile rotated his squad in Denmark on Tuesday, but all the big-hitters will be back for this one.
Thereβs no more big-hitter than Erling Braut HΓ₯land right now; heβs already scored 20 goals this season, averaging one every 47.5 minutes in the Champions and Premier League.
They are without Kyle Walker and Kalvin Phillips, neither of whom are likely to be back in time for the World Cup.
RΓΊben Dias, Bernardo Silva and Phil Foden, who all came off the bench in midweek, will start here.
Kevin De Bruyne has nine Premier League assists to his name; the record for a single-season is 20.
Liverpool vs Manchester City: Match statistics
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