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Match preview
A London derby between two clubs located just 13.4 miles apart.
Queens Park Rangers, given that they play in the division above, come into this one as favourites.
Michael Beale claimed his first victory as QPR boss on Saturday, beating Middlesbrough 3-2 at Loftus Road.
In this competition, the Hoops have only fallen in the first round once since 2010, this coming two years ago when they were beaten by Plymouth.
Charlton Athletic meantime are enduring a third successive season back in League One, following relegation in 2020.
The Addicks drew 2-2 at Accrington on opening day before beating Derby County on Saturday; Corey Blackett-Taylor with the winner.