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Arsenal: Ospina, Bellerin, Chambers, Hayden, Coquelin, Rosicky, Diaby, Wilshere, Alexis, Campbell, Podolski.
Subs: Martinez, Ajayi, Gibbs, Mertesacker, Oxlade-Chamberlain, Cazorla, Akpom
Southampton: Forster, Clyne, Fonte, Gardos, Targett, Wanyama, Schneiderlin, S. Davis, Tadić, Mané, Pellè.
Subs: K. Davis (GK), Long, Cork, Bertrand, Mayuka, Reed, McCarthy.
The Gunners give a debut to David Ospina in goal, while Abou Diaby is back in the team after a long absence through injury.
Joel Campbell also gets a rare start for Arsene Wenger, while Alexis Sanchez is also in the home team.
As for Southampton, new signing Sadio Mané gets his debut for Ronaldo Koeman.