Arsenal v Southampton
For the second time in two years, Arsenal play Southampton in the EFL Cup at The Emirates.
Last time they met in this competition, in 2014, the Saints produced a surprise, coming back from a fine Alexis Sanchez free-kick opener to win thanks to goals from Dusan Tadic and Nathaniel Clyne.
On Wednesday night, two of the form teams in the Premier League will play at The Emirates but it looks likely that both managers will make serious changes.
Giroud misses out
Super sub Olivier Giroud would have been expected to start this match for Arsenal after some important goals off the bench this season. But, the Frenchman has a slight groin injury.
Mathieu Debuchy picked up an injury against Bournemouth so also misses out which means Carl Jenkinson will likely play.
After signing a new contract, third choice goalkeeper Emiliano Martinez is also likely to start.
For the Gunners it will likely be a very similar side to that which beat Nottingham Forest and Reading in previous rounds. With all the focus on the Premier League match against West Ham on Saturday.
Will Claude Puel make major changes?
Since this is a cup quarter final at a big side in the Premier League, with a semi-final at stake, you would think Southampton will play a fairly strong side.
In the last round, when they beat Sunderland 1-0, the Saints fielded a side with only a few first teamers.
For the trip to Arsenal, Dušan Tadić and Matt Targett both remain unavailable. However, Sofiane Boufal and Steven Davis are back after missing the match against Everton.
Puel has also all but ruled out Josh Sims, who made such a stunning debut against Everton on Sunday, with the 19-year-old set for a rest.
Arsenal have already beaten Saints this season
Southampton played at The Emirates in early September. Despite a spirited performance from the Saints, Arsenal won out 2-1 thanks to a late Santi Cazorla penalty.
Tonight will also likely be a very even game. If Southampton play a strong team they will have a real chance of progression.
But, Arsenal’s youngsters and fringe first teamers would give anyone a good game at The Emirates.