Santos 1 – Cruz Azul 3 (Agg. 1-5) (CONCACAF Champions League, March 1, 2011) Emanuel Vila put Cruz Azul ahead on 37 volleying home from a deep cross. After the break goals from Christian Gimenez and Emanuel Vila secured the aggregate victory. Cristian Benitez pulled back a consolation for Santos.
Real Salt Lake 4 – Columbus Crew 1 (Agg. 4-1) (CONCACAF Champions League, March 1, 2011) First half goals from Alvaro Saborio and Javier Morales put RSL in charge. Andres Mendoza pulled one back after the break but further goals by Javier Morales again and Andy Williams (fine long range strike) secured the victory.