Caracas 1 – Club Atletico Penarol 1 (Agg. 1-5) (Copa Libertadores first round second leg, February 2, 2012) Fabian Estoyanoff lashed Penarol into the lead. Edwin Peraza pulled back a consolation for the home side.

Tigres 2 – Union Espanola 2 (Agg. 2-3) (Copa Libertadores first round second leg, February 2, 2012) An early brace from Alan Pulido looked to have put Tigres through but a penalty from Emanuel Herrera and an equaliser on the night from Sebastian Jaime put Union Espanola through.