Defending champion Estudiantes beat Bolivar; Libertad held at home by Peru

Libertad 1 – Universitario Peru 1 (Copa Libertadores, March 23, 2010) A long-distance strike from Victor Hugo Ayala put Libertad ahead in the 55th minute, but Luis Alberto Ramirez equalised with only four minutes remaining.

Estudiantes 2 – Bolivar 0 (Copa Libertadores, March 23, 2010) Jose Ernesto Sosa finished a move with Juan Sebastian Veron five minutes into the second half to open the scoring and Mauro Boselli doubled the lead 13 minutes from time after Marcelo Carrusca crossed from the left.