Universidad Chile 5 – Godoy Cruz 1 (Copa Libertadores, February 22, 2012) Junior Fernandes bagged a hat-trick. Gustavo Lorenzetti and Angelo Henriquez also scored for the home side. Leonardo Sigali had brought the score back to 3-1 for the Argentines.

Velez Sarsfield 3 – Chivas 0 (Copa Libertadores, February 22, 2012) Mauro Obolo clipped home the opener. Federico Insua claimed a late brace.