Once Caldas 2 – Sao Paulo 1 (Copa Libertadores, February 25, 2010) Goalkeeper Rogerio Ceni opened the scoring with a deflected free kick. The home side hit back with goals from Fernando Uribe in the 50th, while Dayro Moreno scored the winner in the 72nd minute, picking up the ball on the halfway line and riding three challenges before firing a low shot into the far corner.
Monterrey 2 – Nacional 1 (Copa Libertadores, February 25, 2010)
Blooming 1 – Lanus 4 (Copa Libertadores, February 25, 2010) Brazilian Luiz Vieira fired the hosts ahead early on with an outstanding shot from outside the box. Lanus were ahead before half-time with playmaker Sebastian Blanco land Paraguayan Santiago Salcedo on target. Lanus forward Diego Lagos then fired second-half double to clinch a first win for the Argentinians in three matches to keep their hopes alive. Blooming remained without a point after three games.
Universitario Peru 0 – Libertad 0 (Copa Libertadores, February 25, 2010)