Fluminense 1 – Arsenal Sarandi 0 (Copa Libertadores, February 7, 2012) A fourth minute strike from Fred earned Flu victory.

Defensor Sporting 0 – Velez Sarsfield 3 (Copa Libertadores, February 7, 2012) David Ospina fired Velez ahead in the first half, while Ivan Obolo secured the win  with a second in the 81st. There was just enough time for Sebastian Dominguez to blast home a lovely free kick to make it 3-0.

Chivas 1 – Deportivo Quito 1 (Copa Libertadores, February 7, 2012) Gustavo Alustiza fired Quito into an early lead. Omar Arellano equalised on 93 with a powerful header.