Bolivar 1 – Union Espanola 3 (Copa Libertadores, February 21, 2012) Edhemir Rodriguez had put the home side in front after just one minute but a stunning goal from distance by Mauro Diaz and further strikes by Emanuel Herrera and Jean Paul Pineda (another golazo) secured the win.

Penarol 0 – Atletico Nacional 4 (Copa Libertadores, February 21, 2012) Jherson Cordoba and Dorlan Pabon both scored twice for the away side.

Cruz Azul 4 – Tachira 0 (Copa Libertadores, February 21, 2012) Adrian Cortes (penalty), Edixon Perea, Javier Orozco and Emanuel Villa were on target for Cruz Azul.

Arsenal 3 – Zamora 0 (Copa Libertadores, February 21, 2012) Jorge Ortiz, Carlos Carbonero and Luciano Leguizamón  notched for the Argentines.