Arsenal Sarandi 1 – Universidad de Chile 2 (Copa Sudamericana quarter-final first leg, November 3, 2011) Eduardo Vargas put Universidad ahead just before half-time but Juan Caffa crossed for Mauro Obolo to equalise shortly after the restart. Gustavo Canales was fouled in the box 10 minutes from time and took the penalty himself, converting to give Universidad de Chile a victory which extends their unbeaten run to 23 matches.

LDU de Quito 1 – Libertad 0 (Copa Sudamericana quarter-final first leg, November 3, 2011) An 89th minute goal from Luis Bolanos gave LDU a narrow advantage to carry into the second leg.