After winning the Coppa Italia on Saturday night, Napoli return to Serie A action to confirm third spot and a place in next season’s Champions League.
Cagliari meanwhile are safe from relegation following two successive victories.
Napoli v Cagliari kicks off at 20:00 UK time on Tuesday May 6, 2014.
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Napoli beat Fiorentina on Saturday night in the Coppa Italia final and a victory against Cagliari means The Viola, currently fourth in Serie A, will not be able to catch Rafa Benitez’s side in third.
Benitez looks set to guide yet another team to Champions League football and it will mark another fine campaign for Napoli.
Cagliari have come through a rocky start to 2014 to put themselves in safety with three games remaining.
Defender Davide Astori is one to look out for, with the Italian constantly linked with Premier League clubs.